Anxiety & Depression 5-HTTLPR Test
Do you have a family history of depression?
You may have the “grouchy” gene, linked to altered serotonin levels and an increased risk of anxiety and depression. Find out with this DNA test.
- Tests the 5-HTTLPR variant of the SLC64A gene
- People with the “grouchy” gene have an increased risk of sad feelings, depression and anxiety
- The “grouchy” gene may decrease your response to antidepressants
- 100% private and confidential online results
Selective serotonin reuptake inhibitors (SSRIs) are antidepressants that are commonly used as first-line treatment of depression. Examples include Prozac, Zoloft and Paxil. However, 30-40% of affected people do not appear to benefit as well from these treatments.
The “grouchy” version of the SLC6A4 gene may explain some of this variation, as it is associated with a decreased response to SSRIs.
The molecular target of SSRIs is the 5-HTT serotonin transporter protein. People with the “grouchy” gene produce lower levels of this protein, therefore, they have a lower number of SSRI targets, which affects the efficacy of these commonly prescribed antidepressants.
Alternative antidepressants may be recommended for patients carrying the “grouchy” gene.
Buccal swab collection